The Ghostbusters discover that New York is once again headed for supernatural doom, with a river of ectoplasmic slime bubbling beneath the city and an ancient sorcerer attempting to possess Dana's baby and be born anew. Reunited with the no-nonsense Zeddemore, nerdy nearsighted Louis, and their ever-industrious secretary Janine, the heroes of the hereafter must put a stop to an enormous underground river of slime ready to rot the roots of the entire Big Apple. It seems that Dana's neighbor, Louis Tully, is also being affected by the strange happenings in the apartment building. When strange apparitions appear in Manhattan, Gilbert and Yates turn to engineer Jillian Holtzmann for help. Armed with proton guns, the Ghostbusters become wildly popular, and they are joined by Winston Zeddmore, who is looking for a job with good pay. Sidelined for five years since they spectacularly rescued New York City from destruction. He wants Dana because he's in love with her.
It seems that Dana's neighbor, Louis Tully, is also being affected by the strange happenings in the apartment building. Their first customer is orchestra cello player Dana Barrett, who was scared out of her apartment on the 22nd floor of a high rise apartment building on Central Park West. Armed with proton packs and plenty of attitude, the four women prepare for an epic battle as more than 1,000 mischievous ghouls descend on Times Square. Peter Venkman, Ray Stantz, and Egon Spengler are three scientists at Columbia University in New York City. While Dana's boss, Janosz Poha, is restoring a painting of a 16th-century tyrant named Vigo Von Homburg Deutschendorf, the painting comes to life. Dana, who is now the divorced mother of an 8-month-old baby named Oscar, works in the restoration department at the Manhattan Museum of Art.
Vigo takes complete control of Janosz and orders Janosz to get Dana to cooperate. Peck is forced to believe the Ghostbusters when New York City is put under siege by an ancient Sumerian God named Gozer the Gozerian, who is channeled through the apartment building that Dana and Louis live in, and the mayor has no choice but to let the Ghostbusters out of jail to face Gozer. Now, if your hometown was on the verge of being sucked down into the 10th level of Hell, who else would you call? When Jack has the Ghostbusters put in the Parkview mental hospital, there is an eclipse and Janosz kidnaps Oscar for Vigo. After this, Peter, Ray, Egon, and Winston re-open Ghostbusters, and mayor's assistant Jack Hardemeyer tries to slow them down any way he can, because he believes the Ghostbusters are frauds who will hurt the mayor's chances of becoming the governor of New York. Their first customer is orchestra cello player Dana Barrett, who was scared out of her apartment on the 22nd floor of a high rise apartment building on Central Park West. Also joining the team is Patty Tolan, a lifelong New Yorker who knows the city inside and out. Armed with proton guns, the Ghostbusters become wildly popular, and they are joined by Winston Zeddmore, who is looking for a job with good pay.
However, when Dana begins to have ghost problems again, the boys come out of retirement only to be promptly arrested. Strange things start happening when Oscar's baby carriage takes off by itself with Oscar in it, and it stops in the middle of 1st Avenue. Paranormal researcher Abby Yates and physicist Erin Gilbert are trying to prove that ghosts exist in modern society. A restraining order has forbidden Peter Venkman, Ray Stantz, Winston Zeddemore, and Egon Spengler from working as Ghostbusters, and as a result, they've had to find other jobs. The Ghostbusters and their lawyer, Louis Tully, refuse to be stopped by Jack. Vigo wants to live again by taking over Oscar's body.
Janosz also has his own agenda. Can the Ghostbusters quell the negative emotions feeding the otherworldly threat and stop the world from being slimed?. When Peter, Ray, and Egon try to help Dana, they are arrested and put on trial for violating the restraining order. The mayor wants the Ghostbusters on the job, and when the mayor hears that Jack had the Ghostbusters put in the Parkview mental hospital, he fires Jack and has the Ghostbusters released to try to rescue Oscar from Vigo, and Vigo intends to make it as hard as possible for the Ghostbusters. When the ghosts of the killer Scoleri Brothers show up at the court room, the judge is forced to remove the restraining order against the guys so they can put the Scoleri Brothers in a ghost trap. . .
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